PP-043 First-line antituberculosis drugs induce long-term alterations in diabetic rats' liver
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چکیده
منابع مشابه
Effects of Long-term Administration of Oral Sodium Nitrate on Liver Enzyme Concentrations in Type 2 Diabetic Male Rats
Introduction: Liver disorders in patients with type 2 diabetes (T2D) are mostly associated with higher serum levels of liver enzymes. This study aimed to investigate the effect of nitrate administration on the serum levels of alanine amino transferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) in rats with T2D. Materials and Methods: In this study, 24 male Wistar ra...
متن کاملAntituberculosis drugs: drug interactions, adverse effects, and use in special situations. Part 1: first-line drugs.
The main objectives of tuberculosis therapy are to cure the patients and to minimize the possibility of transmission of the bacillus to healthy subjects. Adverse effects of antituberculosis drugs or drug interactions (among antituberculosis drugs or between antituberculosis drugs and other drugs) can make it necessary to modify or discontinue treatment. We briefly review the new guidelines for ...
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BACKGROUND/AIMS Dysfunction of the gastrointestinal tract occurs in about 76% of patients who are diabetic for more than 10 years. Although diabetes-related dysfunctions of the stomach such as gastroparesis have been extensively studied over the recent years, studies about the mechanism underlying colonic symptoms in long-term diabetes models are rare. Therefore, the goal of our study was to cl...
متن کاملResistance to first-line antituberculosis drugs in Spain, 2010-2011. RETUBES Study.
INTRODUCTION The magnitude of current resistance to antituberculosis drugs in Spain is unknown. The objective of this study is to describe resistance to first-line antituberculosis drugs and determine the associated factors. METHODS Prospective multicenter study of adult tuberculosis patients with positive Mycobacterium tuberculosis culture and antibiogram including first-line drugs in 32 hos...
متن کاملResistance to first- and second-line antituberculosis drugs in Southern Taiwan: Implications for empirical treatment.
BACKGROUND Multidrug-resistant and extensively drug-resistant tuberculosis infections cause public health concerns worldwide. Local epidemiologic data about the drug resistance of Mycobacterium tuberculosis isolate (Mtb) is critical to guide appropriate empirical therapy to cure patients and restrain the spread of tuberculosis. METHODS Antituberculosis susceptibility testing was performed for...
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ژورنال
عنوان ژورنال: International Journal of Infectious Diseases
سال: 2010
ISSN: 1201-9712
DOI: 10.1016/s1201-9712(10)60111-7